05.01.24 -- Learn How To Reduce Translational Failure Through Next Generation Organ-on-a-Chip Technology

“Microphysiological system” (MPS) broadly refers to any advanced in vitro system that allows cells to be cultured in a more physiologically relevant environment. Unlike traditional 2D cell culture systems, MPS exposes cells to structural, material, or biophysical elements that replicate their native tissue physiology. Learn how drug developers are increasingly integrating MPS into preclinical drug development pipelines.

Drug-induced liver injury (DILI) is a leading cause of safety-related clinical trial failure and market withdrawals. A recent study reported an advanced, three-dimensional culture system that mimics human liver tissue could have saved lives and prevented liver transplants caused by the test set of drugs. See how the Liver-Chip could be used to assess a candidate drug’s likelihood of causing DILI before entering clinical trials.

Organ-on-a-Chip technology enables scientists to overcome many of the challenges with current preclinical models. Researchers can use Organ-Chips to build physiologically relevant in vitro models of inflammation that better model human response. Learn more about developing a more human-relevant model for inflammatory disease modeling and drug development, and the future of inflammatory disease research.

Inflammatory bowel disease (IBD) is a complex pathology with a large, rapidly growing, unmet medical need. The Colon Intestine-Chip was developed as a primary human vascularized model of the intestinal barrier and can be used to model the progression of IBD. Read about how this model provides a unique solution to developing novel anti-inflammatory therapeutics for human intestinal disease.

Traditionally, pharmaceutical development has relied on conventional in vitro and animal models that cannot accurately recreate human biology or response to therapeutics. Discover how one system can model human disease and response to drug candidates right in your lab, providing an open platform for recreating human biology and enabling you to model any organ of interest for any research application.